Structure via PubChem · Public domain (PubChem)
moxisylyte
Sign in to saveMoxisylyte, also known as thymoxamine, is a drug used in urology for the treatment of erectile dysfunction. It is an α1-adrenergic antagonist. In the United Kingdom, Moxisylyte is marketed as Opilon (Archimedes Pharma UK Ltd) and is used for the short-term treatment of primary Raynaud's syndrome. This is a condition where the fingers and toes become discoloured and is triggered by responses to cold, or emotional distress. Opilon tablets help by improving blood circulation to the extremities.
Chemical data
- Formula
- C16H25NO3
- Molecular weight
- 279.37 g/mol
- IUPAC name
- [4-[2-(dimethylamino)ethoxy]-2-methyl-5-propan-2-ylphenyl] acetate
- SMILES
- CC1=CC(=C(C=C1OC(=O)C)C(C)C)OCCN(C)C
- InChIKey
- VRYMTAVOXVTQEF-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 38.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Admin. routes
- oral
- Indications
- cardiovascular disease, erectile dysfunction
via ChEMBL · EBI
Research
375 papers- Moxisylyte: a review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in impotence.Fundamental & clinical pharmacology · 1998
- Raynaud disease.The Journal of hand surgery · 2014
- A review of the clinical pharmacokinetics of pilocarpine, moxisylyte (thymoxamine), and dapiprazole in the reversal of diagnostic pupillary dilation.Optometry and vision science : official publication of the American Academy of Optometry · 1992
- Multiple-dose pharmacokinetics of moxisylyte after oral administration to healthy volunteers.Journal of pharmaceutical sciences · 1993
- [Moxisylyte-induced cytolytic hepatitis?].Gastroenterologie clinique et biologique · 1991
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 279.183444
- Has use
- medication
Show 3 more facts
- chemical formula
- C₁₆H₂₅NO₃
- canonical SMILES
- CC1=CC(=C(C=C1OC(=O)C)C(C)C)OCCN(C)C
- Commons category
- Moxisylyte
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Moxisylyte, also known as thymoxamine, is a drug used in urology for the treatment of erectile dysfunction. It is an α1-adrenergic antagonist. In the United Kingdom, Moxisylyte is marketed as Opilon (Archimedes Pharma UK Ltd) and is used for the short-term treatment of primary Raynaud's syndrome. This is a condition where the fingers and toes become discoloured and is triggered by responses to cold, or emotional distress. Opilon tablets help by improving blood circulation to the extremities.
==References==
Excerpted from Wikipedia’s “moxisylyte” article, available under the CC BY-SA 4.0 licence.
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