Structure via PubChem · Public domain (PubChem)
nilvadipine
Sign in to saveAlso known as CL-287389, Nivadil, FK-235, SK&F-102362
Nilvadipine is a calcium channel blocker (CCB) used for the treatment of hypertension and chronic major cerebral artery occlusion.
Chemical data
- Formula
- C19H19N3O6
- Molecular weight
- 385.4 g/mol
- IUPAC name
- 3-O-methyl 5-O-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- SMILES
- CC1=C(C(C(=C(N1)C#N)C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC(C)C
- InChIKey
- FAIIFDPAEUKBEP-UHFFFAOYSA-N
- XLogP
- 2.9
- Polar surface area
- 134 Ų
- H-bond donors
- 1
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- cardiovascular disease, Alzheimer disease
via ChEMBL · EBI
Research
334 papers- Nilvadipine: profile of a new calcium antagonist. An overview.Journal of cardiovascular pharmacology · 1994
- Pharmacokinetics of nilvadipine.Journal of cardiovascular pharmacology · 1992
- Nilvadipine. A review of its pharmacodynamic and pharmacokinetic properties, therapeutic use in hypertension and potential in cerebrovascular disease and angina.Drugs & aging · 1995
- Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial.PLoS medicine · 2018
- Pharmacodynamics of nilvadipine, a new dihydropyridine-type calcium antagonist.Journal of cardiovascular pharmacology · 1992
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 385.127385
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₉H₁₉N₃O₆
- World Health Organisation international non-proprietary name
- nilvadipine
- canonical SMILES
- CC1=C(C(C(=C(N1)C#N)C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC(C)C
- defined daily dose
- 8
- subject has role
- calcium channel blocker
- medical condition treated
- essential hypertension
- Commons category
- Nilvadipine
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Experimental research
- References
Nilvadipine is a calcium channel blocker (CCB) used for the treatment of hypertension and chronic major cerebral artery occlusion.
Pathohistochemical studies have revealed that the volume of the infarction in the middle cerebral artery occlusion model could be decreased by nilvadipine.
Excerpted from Wikipedia’s “nilvadipine” article, available under the CC BY-SA 4.0 licence.
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