norsalsolinol
Sign in to saveAlso known as 1,2,3,4-tetrahydroisoquinoline-6,7-diol
Norsalsolinol is a tetrahydroisoquinoline that is produced naturally in the body through the metabolism of dopamine. It has been shown to be a selective dopaminergic neurotoxin, and has been suggested as a possible cause of neurodegenerative conditions such as Parkinson's disease and the brain damage associated with alcoholism, although evidence for a causal relationship is unclear.
Wikidata facts
- Mass
- 165.079
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- canonical SMILES
- C1CNCC2=CC(=C(C=C21)O)O
- chemical formula
- C₉H₁₁NO₂
- Commons category
- Norsalsolinol
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Norsalsolinol is a tetrahydroisoquinoline that is produced naturally in the body through the metabolism of dopamine. It has been shown to be a selective dopaminergic neurotoxin, and has been suggested as a possible cause of neurodegenerative conditions such as Parkinson's disease and the brain damage associated with alcoholism, although evidence for a causal relationship is unclear.
The related compound (R)-salsolinol, which has been shown to be a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake in rats.