ondansetron
Also known as ODT032, GR-38032F/GR-38032
Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. It is also effective for treating gastroenteritis. It can be given orally (by mouth), intramuscularly (injection into a muscle), or intravenously (injection into a vein).
Key facts
- Drug.ChEMBL
- 46
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- 477170896
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- Drug.tradename
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- Drug.MedlinePlus
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Article
21 sectionsContents
- Medical uses
- Pregnancy
- Cyclic vomiting syndrome
- Gastroenteritis
- Irritable bowel syndrome (IBS)
- Special populations
- Children
- Adverse effects
- QT prolongation
- Overdose
- Serotonin syndrome
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- History
- Society and culture
- Publication bias
- Availability
- Research
- References
- External links
Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. It is also effective for treating gastroenteritis. It can be given orally (by mouth), intramuscularly (injection into a muscle), or intravenously (injection into a vein).
Common side effects include diarrhea, constipation, headache, sleepiness, and itchiness. Serious side effects include QT prolongation and severe allergic reaction. It appears to be safe during pregnancy but has not been well studied in this group. It is a serotonin 5-HT3 receptor antagonist. It does not have any effect on dopamine receptors or muscarinic acetylcholine receptor and therefore does not cause akathisia.