File:Ondansetron_structure.svg · Wikimedia Commons · See Wikimedia Commons
ondansetron
Sign in to saveAlso known as ODT032, GR-38032F/GR-38032
Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. It is also effective for treating gastroenteritis. It can be given orally (by mouth), intramuscularly (injection into a muscle), or intravenously (injection into a vein).
Key facts
- Drug.ChEMBL
- 46
- Drug.verifiedrevid
- 477170896
- Drug.image
- Ondansetron skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 225
- Drug.image2
- Ondansetron 3D.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250
- Drug.tradename
- Zofran, others
- Drug.MedlinePlus
- a601209
- Drug.DailyMedID
- Ondansetron
- Drug.pregnancy_AU
- B1
- Drug.routes_of_administration
- By mouth, rectal, intravenous, intramuscular, thin film
- Drug.ATC_prefix
- A04
- Drug.ATC_suffix
- AA01
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
via Wikipedia infobox
Chemical data
- Formula
- C18H19N3O
- Molecular weight
- 293.4 g/mol
- IUPAC name
- 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one
- SMILES
- CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C
- InChIKey
- FELGMEQIXOGIFQ-UHFFFAOYSA-N
- XLogP
- 2.3
- Polar surface area
- 39.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Research
5,903 papers- Ondansetron.European journal of cancer (Oxford, England : 1990) · 1993
- Ondansetron.Indian pediatrics · 1995
- Ondansetron clinical pharmacokinetics.Clinical pharmacokinetics · 1995
- Ondansetron for Shivering after Spinal Anesthesia in Cesarean Delivery: A Systematic Review and Meta-analysis.Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses · 2022
- Ondansetron reduces the incidence of hypotension after spinal anaesthesia in non-caesarean delivery: A systematic review and meta-analysis.Journal of perioperative practice · 2022
via PubMed
Wikidata facts
- Mass
- 293.152812
Show 5 more facts
- chemical formula
- C₁₈H₁₉N₃O
- Commons category
- Ondansetron
- World Health Organisation international non-proprietary name
- ondansetron
- canonical SMILES
- CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C
- defined daily dose
- 16
Sources (6)
via Wikidata · CC0
~12 min read
Article
21 sectionsContents
- Medical uses
- Pregnancy
- Cyclic vomiting syndrome
- Gastroenteritis
- Irritable bowel syndrome (IBS)
- Special populations
- Children
- Adverse effects
- QT prolongation
- Overdose
- Serotonin syndrome
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- History
- Society and culture
- Publication bias
- Availability
- Research
- References
- External links
Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. It is also effective for treating gastroenteritis. It can be given orally (by mouth), intramuscularly (injection into a muscle), or intravenously (injection into a vein).
Common side effects include diarrhea, constipation, headache, sleepiness, and itchiness. Serious side effects include QT prolongation and severe allergic reaction. It appears to be safe during pregnancy but has not been well studied in this group. It is a serotonin 5-HT3 receptor antagonist. It does not have any effect on dopamine receptors or muscarinic acetylcholine receptor and therefore does not cause akathisia.