OTOG
Sign in to saveAlso known as DFNB18B, MLEMP, OTGN, otogelin
Otogelin is a protein that in humans is encoded by the OTOG gene.
In the Vinony graph
Within Vinony's link graph, OTOG is referenced by 2 other articles, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 11.
Its subject is documented across 5 Wikipedia language editions.
Gene data
OTOG- Name
- otogelin
- Type
- protein-coding
- Position
- 17,547,259–17,647,150 (+)
- Aliases
- DFNB18B, MLEMP, OTGN
- Ensembl
- ENSG00000188162
- RefSeq RNA
- NM_001277269.2, NM_001292063.2, NM_198497.1
- RefSeq protein
- NP_001264198.1, NP_001278992.1
The protein encoded by this gene is a component of the acellular membranes of the inner ear. Disruption of the orthologous mouse gene shows that it plays a role in auditory and vestibular functions. It is involved in fibrillar network organization, the anchoring of otoconial membranes and cupulae to the neuroepithelia, and likely in sound stimulation resistance. Mutations in this gene cause autosomal recessive nonsyndromic deafness, type 18B. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014].
Gene Ontology
Biological process
Pathways
via MyGene.info
Gene · Ensembl
otogelin
- Symbol
- OTOG
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:17,547,259-17,647,150
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 8421
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/340990
- genetic association
- nonsyndromic deafness
- genomic end
- 17668697
- genomic start
- 17547259
- chromosome
- human chromosome 11
- cytogenetic location
- 11p15.1
- expressed in
- prefrontal cortex
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Deafness
- References
- Further reading
Otogelin is a protein that in humans is encoded by the OTOG gene.
==Function==
Excerpted from Wikipedia’s “OTOG” article, available under the CC BY-SA 4.0 licence.