OTUB2

Also known as C14orf137, OTB2, OTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.

Gene data

OTUB2

Name: OTU deubiquitinase, ubiquitin aldehyde binding 2
Type: protein-coding
Aliases: C14orf137, OTB2, OTU2

This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011].

via MyGene.info

Wikidata facts

Image: Protein OTUB2 PDB 1tff.png

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Further reading

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.

Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.