UBE2M
Sign in to saveAlso known as UBC-RS2, UBC12, hUbc12, ubiquitin conjugating enzyme E2 M
NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.
In the Vinony graph
Vinony's link graph records 111 inbound references to UBE2M, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 19.
Vinony links it to 5 Wikipedia language editions.
Gene data
UBE2M- Name
- ubiquitin conjugating enzyme E2 M
- Type
- protein-coding
- Position
- 58,555,709–58,558,986 (−)
- Aliases
- UBC-RS2, UBC12, hUbc12
- Ensembl
- ENSG00000130725
- RefSeq RNA
- NM_003969.4
- RefSeq protein
- NP_003960.1
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
ubiquitin conjugating enzyme E2 M
- Symbol
- UBE2M
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:58,555,709-58,558,986
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein UBE2M PDB 1y8x.png
Show 7 more facts
- HomoloGene ID
- 2952
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9040
- genomic end
- 58558954
- genomic start
- 59067079
- chromosome
- human chromosome 19
- cytogenetic location
- 19q13.43
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.
Excerpted from Wikipedia’s “UBE2M” article, available under the CC BY-SA 4.0 licence.