Also known as E2-25K, HIP2, HYPG, LIG, UBC1, ubiquitin conjugating enzyme E2 K
Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
via MyGene.info
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Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).