UBE2C

Also known as UBCH10, dJ447F3.2, ubiquitin conjugating enzyme E2 C

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.

In the Vinony graph

Within Vinony's link graph, UBE2C is referenced by 107 other articles, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 20.

Its subject is documented across 6 Wikipedia language editions.

Gene data

UBE2C

Name: ubiquitin conjugating enzyme E2 C
Type: protein-coding
Position: 45,812,561–45,816,965 (+)
Aliases: UBCH10, dJ447F3.2
Ensembl: ENSG00000175063
RefSeq RNA: NM_001281741.2, NM_001281742.2, NM_007019.4, NM_181799.3, NM_181800.3
RefSeq protein: NP_001268670.1, NP_001268671.1, NP_008950.1, NP_861515.1, NP_861516.1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013].

Pathways

Ubiquitin mediated proteolysis - Homo sapiens (human)Adaptive Immune System Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Cell Cycle Disease Immune System APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C-mediated degradation of cell cycle proteins

via MyGene.info

Gene · Ensembl

ubiquitin conjugating enzyme E2 C

Symbol: UBE2C
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:45,812,561-45,816,965
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein UBE2C PDB 1i7k.png

Show 8 more facts

HomoloGene ID: 5096
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/11065
genomic end: 44445596
genomic start: 44441215
chromosome: human chromosome 20
cytogenetic location: 20q13.12
expressed in: trabecular bone

Sources (4)

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Encyclopedic overview

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Contents

References
Further reading

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Excerpted from Wikipedia’s “UBE2C” article, available under the CC BY-SA 4.0 licence.