UBE2E3
Sign in to saveAlso known as UBCH9, UbcM2, ubiquitin conjugating enzyme E2 E3
Ubiquitin-conjugating enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3 gene.
Gene data
UBE2E3- Name
- ubiquitin conjugating enzyme E2 E3
- Type
- protein-coding
- Position
- 180,937,685–181,076,590 (+)
- Aliases
- UBCH9, UbcM2
- Ensembl
- ENSG00000170035
- RefSeq RNA
- NM_001278554.2, NM_001278555.2, NM_006357.4, NM_182678.3, XM_005246244.3
- RefSeq protein
- NP_001265483.1, NP_001265484.1, NP_006348.1, NP_872619.1, XP_005246301.1
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
ubiquitin conjugating enzyme E2 E3
- Symbol
- UBE2E3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:180,937,685-181,076,590
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein UBE2E3 PDB 1y6l.png
Show 8 more facts
- HomoloGene ID
- 4636
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10477
- genomic end
- 181941312
- genomic start
- 181831975
- chromosome
- human chromosome 2
- cytogenetic location
- 2q31.3
- expressed in
- gastrocnemius muscle
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Ubiquitin-conjugating enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3 gene.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Excerpted from Wikipedia’s “UBE2E3” article, available under the CC BY-SA 4.0 licence.