PCDHA6
Sign in to saveAlso known as CNR2, CNRN2, CNRS2, CRNR2, PCDH-ALPHA6, protocadherin alpha 6
Protocadherin alpha-6 is a protein that in humans is encoded by the PCDHA6 gene.
Gene data
PCDHA6- Name
- protocadherin alpha 6
- Type
- protein-coding
- Position
- 140,827,958–141,012,347 (+)
- Aliases
- CNR2, CNRN2, CNRS2, CRNR2, PCDH-ALPHA6
- Ensembl
- ENSG00000291654
- RefSeq RNA
- NM_018909.4, NM_031848.3, NM_031849.3
- RefSeq protein
- NP_061732.1, NP_114036.1, NP_114037.1
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
protocadherin alpha 6
- Symbol
- PCDHA6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:140,827,958-141,012,351
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PCDHA6 PDB 1wuz.png
Show 5 more facts
- HomoloGene ID
- 75098
- exact match
- identifiers.org/ncbigene/56142
- genomic start
- 140207563
- genomic end
- 141012347
- cytogenetic location
- 5q31.3
Sources (3)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Protocadherin alpha-6 is a protein that in humans is encoded by the PCDHA6 gene.
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.