PCDHA9

Also known as PCDH-ALPHA9, protocadherin alpha 9

Protocadherin alpha-9 is a protein that in humans is encoded by the PCDHA9 gene.

Gene data

PCDHA9

Name: protocadherin alpha 9
Type: protein-coding
Aliases: PCDH-ALPHA9

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

protocadherin alpha 9

Symbol: PCDHA9
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:140,847,772-141,012,351
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 129614
exact match: identifiers.org/ncbigene/9752
genomic start: 140847772
genomic end: 141012347
cytogenetic location: 5q31.3

Sources (4)

via Wikidata · CC0

~1 min read

Article

2 sections

Contents

References
Further reading

Protocadherin alpha-9 is a protein that in humans is encoded by the PCDHA9 gene.

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome 5 that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.