pergolide
Sign in to saveAlso known as LY-127809, Permax®, Pergolida, Pergolidum, Prascend
Pergolide, sold under the brand name Permax and Prascend (veterinary) among others, is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Parkinson's disease is associated with reduced dopamine synthesis in the substantia nigra of the brain. Pergolide acts on many of the same receptors as dopamine to increase receptor activity.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 464199003
- Drug.image
- Pergolide structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 165px
- Drug.image2
- PergolideMV.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 225px
- Drug.tradename
- Permax, Prascend (veterinary), others
- Drug.pregnancy_category
- B
- Drug.routes_of_administration
- Oral
- Drug.class
- Dopamine receptor agonist; Antiparkinsonian agent
- Drug.ATC_prefix
- N04
- Drug.ATC_suffix
- BC02
- Drug.legal_BR
- C1
- Drug.legal_CA
- Rx-only
- Drug.legal_US_comment
- Veterinary use only, withdrawn for human use
- Drug.protein_bound
- 90%
via Wikipedia infobox
Research
1,246 papers- Pergolide for levodopa-induced complications in Parkinson's disease.The Cochrane database of systematic reviews · 2000
- Pergolide-associated valvular heart disease.Comprehensive therapy · 2006
- Efficacy of pergolide for the management of equine pituitary pars intermedia dysfunction: A systematic review.Veterinary journal (London, England : 1997) · 2020
- Pergolide. A review of its pharmacological properties and therapeutic potential in Parkinson's disease.Drugs · 1990
- Pergolide in the treatment of patients with early and advanced Parkinson's disease.Clinical neuropharmacology · 2002
via PubMed
Wikidata facts
- Mass
- 314.18167
Show 6 more facts
- chemical formula
- C₁₉H₂₆N₂S
- isomeric SMILES
- CCCN1C[C@@H](C[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34)CSC
- canonical SMILES
- CCCN1CC(CC2C1CC3=CNC4=CC=CC2=C34)CSC
- World Health Organisation international non-proprietary name
- pergolide
- defined daily dose
- 3
- Commons category
- Pergolide
Sources (6)
via Wikidata · CC0
~6 min read
Article
10 sectionsContents
- Medical uses
- Pharmacology
- Pharmacodynamics
- Side effects
- Addictive behaviors
- Society and culture
- Brand names
- Research
- See also
- References
Pergolide, sold under the brand name Permax and Prascend (veterinary) among others, is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Parkinson's disease is associated with reduced dopamine synthesis in the substantia nigra of the brain. Pergolide acts on many of the same receptors as dopamine to increase receptor activity.
It was patented in 1978 and approved for medical use in 1989. In 2007, pergolide was withdrawn from the U.S. market for human use after several published studies revealed a link between the drug and increased rates of valvular heart disease. However, a veterinary form of pergolide, marketed under the trade name Prascend, is permitted for the treatment of pituitary pars intermedia dysfunction (PPID) also known as equine Cushing's syndrome (ECS) in horses.