PLS3
Sign in to saveAlso known as BMND18, T-plastin, plastin 3
Plastin-3 is a highly conserved protein that in humans is encoded by the PLS3 gene on the X chromosome.
In the Vinony graph
Within Vinony's link graph, PLS3 is referenced by 4 other articles, and connects out to PubMed, X chromosome and Ensembl genome database project.
Vinony files it under EF-hand-containing proteins and Genes on human chromosome X.
Its subject is documented across 5 Wikipedia language editions.
Gene data
PLS3- Name
- plastin 3
- Type
- protein-coding
- Chromosome
- X
- Position
- 115,560,914–115,651,439 (+)
- Aliases
- BMND18, DIH5, T-plastin
- Ensembl
- ENSG00000102024
- RefSeq RNA
- NM_001136025.5, NM_001172335.3, NM_001282337.2, NM_001282338.2, NM_001440791.1
- RefSeq protein
- NP_001129497.1, NP_001165806.1, NP_001269266.1, NP_001269267.1, NP_001427720.1
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
plastin 3
- Symbol
- PLS3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr X:115,560,914-115,651,439
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PLS3 PDB 1aoa.png
Show 8 more facts
- HomoloGene ID
- 128200
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5358
- chromosome
- human X chromosome
- genomic start
- 114795501
- genomic end
- 114885181
- cytogenetic location
- Xq23
- genetic association
- osteoporosis
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Plastin-3 is a highly conserved protein that in humans is encoded by the PLS3 gene on the X chromosome.
== Function ==
Excerpted from Wikipedia’s “PLS3” article, available under the CC BY-SA 4.0 licence.