PML

Also known as MYL, PP8675, RNF71, TRIM19, Promyelocytic leukemia protein, promyelocytic leukemia, Probable transcription factor PML, PML nuclear body scaffold

protein-coding gene in the species Homo sapiens

Gene data

PML

Name: PML nuclear body scaffold
Type: protein-coding
Position: 73,994,673–74,047,827 (+)
Aliases: MYL, PP8675, RNF71, TRIM19
Ensembl: ENSG00000140464
RefSeq RNA: NM_002675.4, NM_033238.3, NM_033239.3, NM_033240.3, NM_033244.4
RefSeq protein: NP_002666.1, NP_150241.2, NP_150242.1, NP_150243.2, NP_150247.2

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].