POLB
Sign in to saveAlso known as DNA polymerase beta, polymerase (DNA directed), beta
protein-coding gene in the species Homo sapiens
Gene data
POLB- Name
- DNA polymerase beta
- Type
- protein-coding
- Position
- 42,338,454–42,371,808 (+)
- Ensembl
- ENSG00000070501
- RefSeq RNA
- NM_002690.3, XM_005273535.5, XM_005273536.5, XM_005273537.5, XM_005273538.3
- RefSeq protein
- NP_002681.1, XP_005273592.1, XP_005273593.1, XP_005273594.1, XP_005273595.1
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011].
Gene Ontology
Biological process
Molecular function
Pathways
Base excision repair - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Viral carcinogenesis - Homo sapiens (human)POLB-Dependent Long Patch Base Excision RepairResolution of AP sites via the multiple-nucleotide patch replacement pathwayResolution of AP sites via the single-nucleotide replacement pathwayMetabolism of proteinsAPEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayPCNA-Dependent Long Patch Base Excision RepairDeubiquitination
via MyGene.info
Gene · Ensembl
DNA polymerase beta
- Symbol
- POLB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:42,338,454-42,373,513
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein POLB PDB 1bno.png
Show 4 more facts
- HomoloGene ID
- 2013
- exact match
- identifiers.org/ncbigene/5423
- cytogenetic location
- 8p11.21
- Commons category
- DNA polymerase beta
via Wikidata · CC0
Connections
eukaryote
Entity
Q180686
Entity
messenger RNA
Entity
cis-regulatory element
Entity
mammal
Entity
brain
Entity
liver
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deoxyribonucleic acid
Entity
protein
Entity
International Standard Book Number
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enzyme
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Wikidata
Entity
gene
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testicle
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ribonucleic acid
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spleen
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neuron
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digital object identifier
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domain
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genome
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