PREX2

Also known as 6230420N16Rik, DEP.2, DEPDC2, P-REX2, PPP1R129, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2

Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 gene.

In the Vinony graph

Within Vinony's link graph, PREX2 is referenced by 4 other articles, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 8.

Its subject is documented across 8 Wikipedia language editions.

Gene data

PREX2

Name: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
Type: protein-coding
Aliases: DEP.2, DEPDC2, P-REX2, PPP1R129

The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016].

via MyGene.info