PREX1
Sign in to saveAlso known as P-REX1, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein is a protein that in humans is encoded by the PREX1 gene.
In the Vinony graph
Within Vinony's link graph, PREX1 is referenced by 4 other articles, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 20.
Its subject is documented across 5 Wikipedia language editions.
Gene data
PREX1- Name
- phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
- Type
- protein-coding
- Position
- 48,624,249–48,828,096 (−)
- Aliases
- P-REX1
- Ensembl
- ENSG00000124126
- RefSeq RNA
- NM_020820.4, XM_011528934.2, XM_047440331.1, XM_047440332.1, XM_047440333.1
- RefSeq protein
- NP_065871.3, XP_011527236.1, XP_047296287.1, XP_047296288.1, XP_047296289.1
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
- Symbol
- PREX1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:48,624,249-48,828,096
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- exact match
- identifiers.org/ncbigene/57580
- HomoloGene ID
- 10821
- found in taxon
- Homo sapiens
- chromosome
- human chromosome 20
- genomic start
- 47240790
- genomic end
- 48827999
- cytogenetic location
- 20q13.13
- expressed in
- substantia nigra
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein is a protein that in humans is encoded by the PREX1 gene.
== Function ==
Excerpted from Wikipedia’s “PREX1” article, available under the CC BY-SA 4.0 licence.