programmed cell death 1

Protein · UniProt

Programmed cell death protein 1

Gene

PDCD1

Organism

Homo sapiens (Human)

Length

288 aa

Molecular mass

31,647 Da

Evidence

1: Evidence at protein level

Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005, PubMed:31754127, PubMed:32184441, PubMed:37208329). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005, PubMed:26602187). Following T-cell receptor (TCR) engagement, PDCD1 associates with TCR-CD3 in the immunological synapse and directly inhibits T-cell activation (PubMed:32184441). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosph…

• Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.The EMBO journal · 1992
• Programmed cell death-1 and its ligands: Current knowledge and possibilities in immunotherapy.Clinics (Sao Paulo, Brazil) · 2023
• Programmed cell death-1 blockade therapy in melanoma: Resistance mechanisms and combination strategies.Experimental dermatology · 2023
• Programmed Cell Death 1 and Hepatocellular Carcinoma: An Epochal Story.Journal of gastrointestinal cancer · 2021
• Programmed Cell Death Protein 1 (PD-1) in Relation to PANoptosis: Immune Pharmacological Targets for Management of Breast Adenocarcinoma.Endocrine, metabolic & immune disorders drug targets · 2023

via PubMed

• PHASE3COMPLETED
  Safety and Efficacy of Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) Versus Lenvatinib as First-line Therapy in Participants With Advanced Hepatocellular Carcinoma (MK-7902-002/E7080-G000-311/LEAP-002)Merck Sharp & Dohme LLC · NCT03713593
• PHASE2UNKNOWN
  Dietary Intervention in Follicular LymphomaOslo University Hospital · NCT00455416
• PHASE3RECRUITING
  A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)Merck Sharp & Dohme LLC · NCT06623422
• PHASE3UNKNOWN
  PD1 Antibody and Lenalidomide as a Treatment for EBV-HLH or CAEBVBeijing Friendship Hospital · NCT04084626
• PHASE2COMPLETED
  Study of Favezelimab Coformulated With Pembrolizumab (MK-4280A) in Participants With Selected Solid Tumors (MK-4280A-010)Merck Sharp & Dohme LLC · NCT06036836
• PHASE2UNKNOWN
  Induction Chemotherapy Combined With Immunotherapy for Locally Advanced Hypopharyngeal CarcinomaEye & ENT Hospital of Fudan University · NCT04156698

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

via Wikidata · CC0