ICOS

Also known as AILIM, CD278, CVID1, inducible T-cell co-stimulator, inducible T-cell costimulator, inducible T cell costimulator

Inducible T-cell costimulator (also called CD278) is an immune checkpoint protein that in humans is encoded by the ICOS (Inducible T-cell COStimulator) gene. The protein belongs to the CD28 and CTLA-4 cell-surface receptor family. These are proteins expressed on the surface of immune cells that mediate signalling between them. A surface protein, the ligand, binds specifically to its receptor on another cell, leading to a signalling cascade in that cell.

Gene data

ICOS

Name: inducible T cell costimulator
Type: protein-coding
Position: 203,936,763–203,961,577 (+)
Aliases: AILIM, CD278, CVID1
Ensembl: ENSG00000163600
RefSeq RNA: NM_012092.4, XM_047444022.1, XM_054341553.1, XR_007073112.1, XR_008486351.1
RefSeq protein: NP_036224.1, XP_047299978.1, XP_054197528.1

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

T cell tolerance induction immune response T cell costimulation

~3 min read

Article

6 sections

Contents

Function
Knockout phenotype
Combination therapy
References
Further reading
External links

Inducible T-cell costimulator (also called CD278) is an immune checkpoint protein that in humans is encoded by the ICOS (Inducible T-cell COStimulator) gene.

The protein belongs to the CD28 and CTLA-4 cell-surface receptor family. These are proteins expressed on the surface of immune cells that mediate signalling between them. A surface protein, the ligand, binds specifically to its receptor on another cell, leading to a signalling cascade in that cell.