CD4 molecule

Also known as CD4 Antigens, T-cell surface antigen T4/Leu-3, CD4 receptor, CD4 antigen (p55), T-cell surface glycoprotein CD4, CD4, CD4 protein

thumb|Image of CD4 co-receptor binding to MHC (Major Histocompatibility Complex) non-polymorphic region.

Key facts

Protein family.Symbol: CD4-extrcel
Protein family.Name: CD4, Cluster of differentiation 4, extracellular
Protein family.image: PDB 1wip EBI.jpg
Protein family.caption: structure of T cell surface glycoprotein cd4, monoclinic crystal form
Protein family.Pfam: PF09191
Protein family.InterPro: IPR015274
Protein family.SCOP: 1cid
Protein family.OPM family: 193
Protein family.OPM protein: 2klu
Protein family.CDD: cd07695
Protein family.Membranome family: 27

via Wikipedia infobox

Protein · UniProt

T-cell surface glycoprotein CD4

Gene: CD4
Organism: Homo sapiens (Human)
Length: 458 aa
Molecular mass: 51,111 Da
Evidence: 1: Evidence at protein level

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 …

3D-structureAdaptive immunityCell membraneDirect protein sequencingDisulfide bondGlycoproteinHost cell receptor for virus entryHost-virus interaction

View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Clinical Trials

1 registered

PHASE1/PHASE2RECRUITING
CAR-T Cells for HIV InfectionSteven Deeks · NCT04648046

via ClinicalTrials.gov

Wikidata facts

Show 2 more facts

exact match: purl.uniprot.org/uniprot/P01730
Commons category: CD4

Sources (3)

via Wikidata · CC0

~7 min read

Article

11 sections

Contents

Structure
Function
Other interactions
Disease
HIV infection
HIV pathology
Other diseases
See also
References
Further reading
External links

thumb|Image of CD4 co-receptor binding to MHC (Major Histocompatibility Complex) non-polymorphic region.

In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene.