CD4

Also known as CD4 Antigens, T-cell surface antigen T4/Leu-3, CD4 receptor, CD4 antigen (p55), T-cell surface glycoprotein CD4, CD4 protein

protein

In the Vinony graph

Within Vinony's link graph, CD4 is referenced by 1,153 other articles, and connects out to T helper cell, CD8 and PubMed.

It sits within the topics Clusters of differentiation, Genes on human chromosome 12 and Glycoproteins.

Its subject is documented across 24 Wikipedia language editions.

Key facts

Protein family.Symbol: CD4-extrcel
Protein family.Name: CD4, Cluster of differentiation 4, extracellular
Protein family.image: PDB 1wip EBI.jpg
Protein family.caption: structure of T cell surface glycoprotein cd4, monoclinic crystal form
Protein family.Pfam: PF09191
Protein family.InterPro: IPR015274
Protein family.SCOP: 1cid
Protein family.OPM family: 193
Protein family.OPM protein: 2klu
Protein family.CDD: cd07695
Protein family.Membranome family: 27

via Wikipedia infobox

Protein · UniProt

T-cell surface glycoprotein CD4

Gene: CD4
Organism: Homo sapiens (Human)
Length: 458 aa
Molecular mass: 51,111 Da
Evidence: 1: Evidence at protein level

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 …

3D-structureAdaptive immunityCell membraneDirect protein sequencingDisulfide bondGlycoproteinHost cell receptor for virus entryHost-virus interaction

View on UniProt →

Swiss-Prot (reviewed) · via UniProt