File:Propofol.svg · Wikimedia Commons · See Wikimedia Commons
propofol
Sign in to saveAlso known as 2,6-diisopropylphenol, ICI 35868, 2,6-bis(1-methylethyl)phenol, 2,6-di(propan-2-yl)phenol
Propofol is the active component of an intravenous anesthetic formulation used for induction and maintenance of general anesthesia. The formulation was approved under the brand name Diprivan. Numerous generic versions have since been released. Intravenous administration is used to induce unconsciousness, after which anesthesia may be maintained using a combination of medications. It is manufactured as part of a sterile injectable emulsion formulation using soybean oil and lecithin, giving it a white milky coloration.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 456484691
- Drug.image
- Propofol.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Propofol ball-and-stick model from xtal 2014.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Ball-and-stick model of propofol
- Drug.tradename
- Diprivan, others
- Drug.DailyMedID
- Propofol
- Drug.pregnancy_AU
- C
- Drug.addiction_liability
- Moderate
- Drug.dependency_liability
- Physical: Very high Psychological: no data
- Drug.routes_of_administration
- Intravenous
- Drug.class
- GABAA receptor agonist;sedative;general anesthetic
- Drug.ATC_prefix
- N01
- Drug.ATC_suffix
- AX10
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
via Wikipedia infobox
Chemical data
- Formula
- C12H18O
- Molecular weight
- 178.27 g/mol
- IUPAC name
- 2,6-di(propan-2-yl)phenol
- SMILES
- CC(C)C1=C(C(=CC=C1)C(C)C)O
- InChIKey
- OLBCVFGFOZPWHH-UHFFFAOYSA-N
- XLogP
- 3.8
- Polar surface area
- 20.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Research
29,528 papers- Propofol: Milk of Amnesia.Cell · 2018
- Propofol infusion syndrome: a structured literature review and analysis of published case reports.British journal of anaesthesia · 2019
- Propofol: A Medication That Changed Pediatric Anesthesia Practice.Paediatric anaesthesia · 2025
- Propofol.Dimensions of critical care nursing : DCCN · 2001
- [Propofol: use, toxicology and assay features].Sudebno-meditsinskaia ekspertiza · 2022
via PubMed
Wikidata facts
- Mass
- 178.136
Show 8 more facts
- Commons category
- Propofol
- chemical formula
- C₁₂H₁₈O
- canonical SMILES
- CC(C)C1=C(C(=CC=C1)C(C)C)O
- World Health Organisation international non-proprietary name
- propofolum
- melting point
- 18
- boiling point
- 247
- density
- 0.955
- refractive index
- 1.5140
via Wikidata · CC0
~17 min read
Article
21 sectionsContents
- Uses
- Anesthesia
- Routine procedural sedation
- COVID-19
- Status epilepticus
- Other uses
- Assisted death in Canada
- Capital punishment
- Recreational use
- Manufacturing
- Side effects
- Propofol infusion syndrome
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- History
- Developments
- Veterinary uses
- References
- External links
Propofol is the active component of an intravenous anesthetic formulation used for induction and maintenance of general anesthesia. The formulation was approved under the brand name Diprivan. Numerous generic versions have since been released. Intravenous administration is used to induce unconsciousness, after which anesthesia may be maintained using a combination of medications. It is manufactured as part of a sterile injectable emulsion formulation using soybean oil and lecithin, giving it a white milky coloration.
Compared to other anesthetic agents, recovery from propofol-induced anesthesia is generally rapid and associated with less frequent side effects (e.g., drowsiness, nausea, vomiting). Propofol may be used prior to diagnostic procedures requiring anesthesia, in the management of refractory status epilepticus, and for induction or maintenance of anesthesia prior to and during surgeries. It may be administered as a bolus or an infusion, or as a combination of the two.