RAG1
Sign in to saveAlso known as RAG-1, RNF74, recombination activating gene 1, recombination activating 1
Recombination activating gene 1 also known as RAG-1 is a protein that in humans is encoded by the RAG1 gene.
In the Vinony graph
Within Vinony's link graph, RAG1 is referenced by 28 other articles, and connects out to PubMed, Ensembl genome database project and fish.
It is catalogued under the topic Genes on human chromosome 11.
Its subject is documented across 7 Wikipedia language editions.
Gene data
RAG1- Name
- recombination activating 1
- Type
- protein-coding
- Aliases
- RAG-1, RNF74
The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
recombination activating 1
- Symbol
- RAG1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:36,510,348-36,593,156
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
3,587 papers- Gene therapy strategies for RAG1 deficiency: Challenges and breakthroughs.Immunology letters · 2024
- Rag1 Deficiency Impairs Arteriogenesis in Mice.International journal of molecular sciences · 2023
- How RAG1/2 evolved from ancestral transposases to initiate V(D)J recombination without transposition.Proceedings of the National Academy of Sciences of the United States of America · 2025
- RAG1 and RAG2 in V(D)J recombination and transposition.Immunologic research · 2001
- Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency.Science translational medicine · 2024
via PubMed
Wikidata facts
- Instance of
- gene
Show 7 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 387
- exact match
- identifiers.org/ncbigene/5896
- genomic end
- 36614706
- genomic start
- 36532259
- chromosome
- human chromosome 11
- cytogenetic location
- 11p12
via Wikidata · CC0
~3 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- Use in phylogenetics
- References
Recombination activating gene 1 also known as RAG-1 is a protein that in humans is encoded by the RAG1 gene.
The RAG1 and RAG2 genes are largely conserved in humans. 55.99% and 55.98% of the encoded amino acids contain no reported variants, respectively.
Excerpted from Wikipedia’s “RAG1” article, available under the CC BY-SA 4.0 licence.