RAG2
Sign in to saveAlso known as RAG-2, recombination activating gene 2, recombination activating 2
Recombination activating gene 2 protein (also known as RAG-2) is a lymphocyte-specific protein encoded by the RAG2 gene on human chromosome 11. Together with the RAG1 protein, RAG2 forms a V(D)J recombinase, a protein complex required for the process of V(D)J recombination during which the variable regions of immunoglobulin and T cell receptor genes are assembled in developing B and T lymphocytes. Therefore, RAG2 is essential for the generation of mature B and T lymphocytes.
In the Vinony graph
Within Vinony's link graph, RAG2 is referenced by 21 other articles, and connects out to PubMed, N-terminus and human chromosome 11.
It is catalogued under the topic Genes on human chromosome 11.
Its subject is documented across 8 Wikipedia language editions.
Gene data
RAG2- Name
- recombination activating 2
- Type
- protein-coding
- Position
- 36,575,574–36,598,279 (−)
- Aliases
- RAG-2
- Ensembl
- ENSG00000175097
- RefSeq RNA
- NM_000536.4, NM_001243785.2, NM_001243786.2, NR_033666.1, XM_047427385.1
- RefSeq protein
- NP_000527.2, NP_001230714.1, NP_001230715.1, XP_047283341.1, XP_047283342.1
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
recombination activating 2
- Symbol
- RAG2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:36,575,574-36,598,279
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 7507
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5897
- genomic end
- 36619829
- genomic start
- 36597124
- chromosome
- human chromosome 11
- cytogenetic location
- 11p12
- expressed in
- muscle tissue
Sources (7)
via Wikidata · CC0
~4 min read
Encyclopedic overview
5 sectionsContents
- Structure
- Function
- Clinical significance
- RAG2 knockout mice
- References
Recombination activating gene 2 protein (also known as RAG-2) is a lymphocyte-specific protein encoded by the RAG2 gene on human chromosome 11. Together with the RAG1 protein, RAG2 forms a V(D)J recombinase, a protein complex required for the process of V(D)J recombination during which the variable regions of immunoglobulin and T cell receptor genes are assembled in developing B and T lymphocytes. Therefore, RAG2 is essential for the generation of mature B and T lymphocytes.
== Structure == RAG2 is a 527-amino acid long protein. Its N-terminal part is thought to form a six-bladed propeller in the active core. RAG2 is conserved among all species that carry out V(D)J recombination and its expression pattern correlates precisely with V(D)J recombinase activity. RAG2 is expressed in immature lymphoid cells. While the amount of RAG1 is constant during the cell cycle, the RAG2 accumulates mainly in the G0 and G1 phases of the cell cycle and it undergoes rapid degradation when the cell enters the S phase. This serves as an important regulatory mechanism of V(D)J recombination and a prevention of genomic instability.
Excerpted from Wikipedia’s “RAG2” article, available under the CC BY-SA 4.0 licence.