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GeneQ18028435· pop 6· linked from 357 articles

LAIR2

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Also known as CD306, leukocyte associated immunoglobulin like receptor 2

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.

Gene data

LAIR2
Name
leukocyte associated immunoglobulin like receptor 2
Type
protein-coding
Position
54,497,879–54,510,694 (+)
Aliases
CD306
Ensembl
ENSG00000277335
RefSeq RNA
NM_002288.6, NM_021270.5, XM_011526961.3, XM_054320988.1, XM_054329681.1
RefSeq protein
NP_002279.2, NP_067154.1, XP_011525263.1, XP_054176963.1, XP_054185656.1

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013].

Gene Ontology

Pathways

Adaptive Immune SystemImmune SystemImmunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

via MyGene.info

Gene · Ensembl

leukocyte associated immunoglobulin like receptor 2

Symbol
LAIR2
Biotype
Protein coding
Organism
Homo sapiens
Location
19:54,497,879-54,510,694
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

2 sections
Contents
  • References
  • Further reading

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene.

Excerpted from Wikipedia’s “LAIR2” article, available under the CC BY-SA 4.0 licence.

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via Wikidata sitelinks · CC0