VPREB1

Also known as IGI, IGVPB, VPREB, CD179a, pre-B lymphocyte 1, V-set pre-B cell surrogate light chain 1

Immunoglobulin iota chain is a protein that in humans is encoded by the VPREB1 gene. VPREB1 has also recently been designated CD179A (cluster of differentiation 179A).

In the Vinony graph

Vinony's link graph records 359 inbound references to VPREB1, and connects out to PubMed, Ensembl genome database project and CD1.

Vinony files it under Clusters of differentiation and Genes on human chromosome 22.

Vinony links it to 5 Wikipedia language editions.

Gene data

VPREB1

Name: V-set pre-B cell surrogate light chain 1
Type: protein-coding
Position: 22,244,780–22,245,515 (+)
Aliases: CD179a, IGI, IGVPB, VPREB
Ensembl: ENSG00000169575
RefSeq RNA: NM_001303509.2, NM_007128.4
RefSeq protein: NP_001290438.1, NP_009059.1

The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].

Gene Ontology

Biological process

immune response

Cellular component

extracellular region extracellular region endoplasmic reticulum endoplasmic reticulum immunoglobulin complex

Pathways

Hemostasis Cell surface interactions at the vascular wall

via MyGene.info

Gene · Ensembl

V-set pre-B cell surrogate light chain 1

Symbol: VPREB1
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:22,244,780-22,245,515
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein VPREB1 PDB 2h32.png

Show 8 more facts

HomoloGene ID: 84741
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/7441
genomic end: 22599927
genomic start: 22244780
chromosome: human chromosome 22
cytogenetic location: 22q11.22
expressed in: appendix

Sources (4)

via Wikidata · CC0

~2 min read

Encyclopedic overview

4 sections

Contents

Function
References
Further reading
External links

Immunoglobulin iota chain is a protein that in humans is encoded by the VPREB1 gene. VPREB1 has also recently been designated CD179A (cluster of differentiation 179A).

== Function ==

Excerpted from Wikipedia’s “VPREB1” article, available under the CC BY-SA 4.0 licence.