VPS11

Also known as END1, PEP5, RNF108, hVPS11, HLD12, VPS11, CORVET/HOPS core subunit, VPS11 core subunit of CORVET and HOPS complexes

Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.

In the Vinony graph

Vinony's link graph records 5 inbound references to VPS11, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 11.

Vinony links it to 5 Wikipedia language editions.

Gene data

VPS11

Name: VPS11 core subunit of CORVET and HOPS complexes
Type: protein-coding
Position: 119,067,789–119,082,753 (+)
Aliases: DYT32, END1, HLD12, HLD12; DYT32, PEP5, RNF108, hVPS11
Ensembl: ENSG00000280616
RefSeq RNA: NM_001290185.2, NM_001378218.1, NM_001378219.1, NM_001378220.1, NM_001378221.1
RefSeq protein: NP_001277114.1, NP_001365147.1, NP_001365148.1, NP_001365149.1, NP_001365150.1

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].