VPS52

Also known as ARE1, SAC2, SACM2L, dJ1033B10.5, VPS52, GARP complex subunit, VPS52 subunit of GARP complex

Vacuolar protein sorting-associated protein 52 homolog is a protein that in humans is encoded by the VPS52 gene.

In the Vinony graph

Within Vinony's link graph, VPS52 is referenced by 2 other articles, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 6.

Its subject is documented across 7 Wikipedia language editions.

Gene data

VPS52

Name: VPS52 subunit of GARP complex
Type: protein-coding
Chromosome: HSCHR6_MHC_QBL_CTG1
Position: 4,444,672–4,466,464 (−)
Aliases: ARE1, SAC2, SACM2L, dJ1033B10.5
Ensembl: ENSG00000223618
RefSeq RNA: NM_001289174.2, NM_001289175.1, NM_001289176.1, NM_022553.6, XM_011514797.2
RefSeq protein: NP_001276103.1, NP_001276104.1, NP_001276105.1, NP_072047.4, XP_011513099.1

This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

Gene Ontology

Biological process

protein targeting lysosomal transport lysosomal transport endocytic recycling endocytic recycling endocytic recycling retrograde transport, endosome to Golgi retrograde transport, endosome to Golgi

Molecular function

protein binding syntaxin binding syntaxin binding

Cellular component

GARP complex GARP complex GARP complex Golgi apparatus Golgi apparatus cytosol endosome membrane endosome membrane

Pathways

Membrane Trafficking Vesicle-mediated transport Retrograde transport at the Trans-Golgi-Network Intra-Golgi and retrograde Golgi-to-ER traffic

via MyGene.info

Gene · Ensembl

VPS52 subunit of GARP complex

Symbol: VPS52
Biotype: Protein coding
Organism: Homo sapiens
Location: Chr HSCHR6_MHC_SSTO_CTG1:4,698,976-4,720,728
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 5756
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/6293
genomic end: 33239824
genomic start: 33218049
chromosome: human chromosome 6
cytogenetic location: 6p21.32

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Vacuolar protein sorting-associated protein 52 homolog is a protein that in humans is encoded by the VPS52 gene.

This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18.

Excerpted from Wikipedia’s “VPS52” article, available under the CC BY-SA 4.0 licence.