VPS72

Name

vacuolar protein sorting 72 homolog

Type

protein-coding

Position

151,176,304–151,195,321 (−)

Aliases

Swc2, TCFL1, YL-1, YL1

Ensembl

ENSG00000163159

RefSeq RNA

NM_001271087.2, NM_001271088.2, NM_005997.3, XM_017002205.2, XM_054338527.1

RefSeq protein

NP_001258016.1, NP_001258017.1, NP_005988.1, XP_016857694.1, XP_054194502.1

The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012].

via MyGene.info

Gene · Ensembl

vacuolar protein sorting 72 homolog

Symbol

VPS72

Biotype

Protein coding

Organism

Homo sapiens

Location

1:151,176,304-151,195,321

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0