Also known as CFL1, Swc2, TCFL1, YL-1, YL1, vacuolar protein sorting 72 homolog
Vacuolar protein sorting-associated protein 72 homolog is a protein that in humans is encoded by the VPS72 gene.
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012].
Biological process
Vacuolar protein sorting-associated protein 72 homolog is a protein that in humans is encoded by the VPS72 gene.
== References ==
via MyGene.info
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).