VPS37A

Also known as HCRP1, PQBP2, SPG53, VPS37A, ESCRT-I subunit

Vacuolar protein sorting 37 homolog A (S. cerevisiae) is a protein in humans that is encoded by the VPS37A gene. It is a member of the endosomal sorting complex required for transport (ESCRT) system.

In the Vinony graph

Vinony's link graph records 4 inbound references to VPS37A, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 8.

Vinony links it to 6 Wikipedia language editions.

Gene data

VPS37A

Name: VPS37A subunit of ESCRT-I
Type: protein-coding
Position: 17,246,896–17,333,474 (+)
Aliases: HCRP1, PQBP2, SPG53
Ensembl: ENSG00000155975
RefSeq RNA: NM_001145152.2, NM_001363167.1, NM_001363168.1, NM_001363169.1, NM_001363170.1
RefSeq protein: NP_001138624.1, NP_001350096.1, NP_001350097.1, NP_001350098.1, NP_001350099.1

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012].

Gene Ontology

Biological process

protein targeting to membrane protein targeting to vacuole macroautophagy macroautophagy multivesicular body assembly multivesicular body assembly multivesicular body assembly viral budding via host ESCRT complex

Molecular function

protein binding

Cellular component

ESCRT I complex ESCRT I complex ESCRT I complex ESCRT I complex ESCRT I complex nucleus nucleoplasm endosome membrane

Pathways

Endocytosis - Homo sapiens (human)HIV Life Cycle Budding and maturation of HIV virion Late Phase of HIV Life Cycle HIV Infection Disease Membrane binding and targetting of GAG proteins Synthesis And Processing Of GAG, GAGPOL Polyproteins Assembly Of The HIV Virion Membrane Trafficking

via MyGene.info

Gene · Ensembl

VPS37A subunit of ESCRT-I

Symbol: VPS37A
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:17,246,896-17,333,474
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 45120
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/137492
chromosome: human chromosome 8
genomic start: 17104080
genomic end: 17159936
cytogenetic location: 8p22

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Clinical significance
References
Further reading

Vacuolar protein sorting 37 homolog A (S. cerevisiae) is a protein in humans that is encoded by the VPS37A gene. It is a member of the endosomal sorting complex required for transport (ESCRT) system.

== Clinical significance ==

Excerpted from Wikipedia’s “VPS37A” article, available under the CC BY-SA 4.0 licence.