Ramoplanin
Sign in to saveRamoplanin (INN) is a glycolipodepsipeptide antibiotic drug derived from strain ATCC 33076 of Actinoplanes. It is effective against Gram-positive bacteria.
Research
197 papers- Ramoplanin: a lipoglycodepsipeptide antibiotic.The Annals of pharmacotherapy · 2005
- Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent.Expert review of anti-infective therapy · 2006
- Ramoplanin as a novel therapy for Neisseria gonorrhoeae infection: an in vitro and in vivo study in Galleria mellonella.Journal of medical microbiology · 2024
- Chemistry and biology of the ramoplanin family of peptide antibiotics.Biopolymers · 2002
- Ramoplanin: a novel antimicrobial agent with the potential to prevent vancomycin-resistant enterococcal infection in high-risk patients.The Journal of antimicrobial chemotherapy · 2003
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Encyclopedic overview
6 sectionsContents
- Medical uses
- Mechanism of action
- Chemistry
- Biosynthesis
- Total synthesis
- References
Ramoplanin (INN) is a glycolipodepsipeptide antibiotic drug derived from strain ATCC 33076 of Actinoplanes. It is effective against Gram-positive bacteria.
== Medical uses == Its development has been fast-tracked by the U.S. Food and Drug Administration as a treatment for multiple antibiotic-resistant Clostridioides difficile infection of the gastrointestinal tract, Unlike vancomycin, it is absorbed in the gastrointestinal tract, although it is unstable in the bloodstream, so can be taken only orally against Clostridioides difficile infections of the gastrointestinal tract.
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