RCC2

Also known as TD-60, regulator of chromosome condensation 2

Protein RCC2 also known as telophase disk protein of 60 kDa (TD-60) or RCC1-like protein TD-60 is a protein that in humans is encoded by the RCC2 gene.

Gene data

RCC2

Name: regulator of chromosome condensation 2
Type: protein-coding
Position: 17,406,755–17,439,772 (−)
Aliases: TD-60
Ensembl: ENSG00000281540
RefSeq RNA: NM_001136204.3, NM_018715.4
RefSeq protein: NP_001129676.1, NP_061185.1

The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal cancer. [provided by RefSeq, Oct 2016].

Pathways

Amplification of signal from the kinetochores Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Signal Transduction Cell Cycle Signaling by Rho GTPases RHO GTPase Effectors Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase RHO GTPases Activate Formins

via MyGene.info

Gene · Ensembl

regulator of chromosome condensation 2

Symbol: RCC2
Biotype: Protein coding
Organism: Homo sapiens
Location: Chr HG2095_PATCH:251,983-284,900
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 10282
genomic start: 17733256
exact match: identifiers.org/ncbigene/55920
genomic end: 17439677
cytogenetic location: 1p36.13

Sources (4)

via Wikidata · CC0

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Article

4 sections

Contents

Function
References
Further reading
External links

Protein RCC2 also known as telophase disk protein of 60 kDa (TD-60) or RCC1-like protein TD-60 is a protein that in humans is encoded by the RCC2 gene.

== Function ==