RHBDF2
Sign in to saveAlso known as RHBDL5, RHBDL6, TOC, TOCG, TEC, iRhom2, rhomboid 5 homolog 2
Inactive rhomboid protein 2 is a protein that in humans is encoded by the RHBDF2 gene. The alternative name iRhom2 has been proposed, in order to clarify that it is a catalytically inactive member of the rhomboid family of intramembrane serine proteases.
Gene data
RHBDF2- Name
- rhomboid 5 homolog 2
- Type
- protein-coding
- Aliases
- RHBDL5, RHBDL6, TOC, TOCG, iRhom2
Predicted to enable protein transporter activity. Predicted to be involved in negative regulation of protein secretion and regulation of epidermal growth factor receptor signaling pathway. Located in plasma membrane. Implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
rhomboid 5 homolog 2
- Symbol
- RHBDF2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:76,470,884-76,501,790
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 11612
- exact match
- identifiers.org/ncbigene/79651
- genomic end
- 74497872
- genomic start
- 74466973
- cytogenetic location
- 17q25.1
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Inactive rhomboid protein 2 is a protein that in humans is encoded by the RHBDF2 gene. The alternative name iRhom2 has been proposed, in order to clarify that it is a catalytically inactive member of the rhomboid family of intramembrane serine proteases.
The RHBDF2 gene is located on the long arm of chromosome 17 (17q25.1) on the Crick (minus) strand. It is 30.534 kilobases in length and encodes a protein of 856 amino acids with a predicted molecular weight of 96.686 kilodaltons.