Structure via PubChem · Public domain (PubChem)
Robalzotan
Sign in to saveAlso known as AZD-7371, NAD 299, NAD-299, NAD299, robalzotan tartrate hydrate
Robalzotan (, ; developmental code names NAD-299, AZD-7371) is a selective antagonist at the serotonin 5-HT1A receptor which was under development for the treatment of major depressive disorder, anxiety disorders, gastrointestinal disorders, irritable bowel syndrome (IBS), and overactive bladder.
Chemical data
- Formula
- C18H23FN2O2
- Molecular weight
- 318.4 g/mol
- IUPAC name
- (3R)-3-[di(cyclobutyl)amino]-8-fluoro-3,4-dihydro-2H-chromene-5-carboxamide
- SMILES
- C1CC(C1)N([C@@H]2CC3=C(C=CC(=C3OC2)F)C(=O)N)C4CCC4
- InChIKey
- MQTUXRKNJYPMCG-CYBMUJFWSA-N
- XLogP
- 2.8
- Polar surface area
- 55.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 318.174356
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₈H₂₃FN₂O₂
- isomeric SMILES
- C1CC(C1)N([C@@H]2CC3=C(C=CC(=C3OC2)F)C(=O)N)C4CCC4
- canonical SMILES
- C1CC(C1)N(C2CCC2)C3CC4=C(C=CC(=C4OC3)F)C(=O)N
- physically interacts with
- 5-hydroxytryptamine receptor 1A
- Commons category
- Robalzotan
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Robalzotan (, ; developmental code names NAD-299, AZD-7371) is a selective antagonist at the serotonin 5-HT1A receptor which was under development for the treatment of major depressive disorder, anxiety disorders, gastrointestinal disorders, irritable bowel syndrome (IBS), and overactive bladder.
It was shown to completely reverse the autoreceptor-mediated inhibition of serotonin release induced by the administration of selective serotonin reuptake inhibitors (SSRIs) like citalopram in rodent studies.
Excerpted from Wikipedia’s “Robalzotan” article, available under the CC BY-SA 4.0 licence.