(RS)-amisulpride
Also known as (±)-amisulpride, 4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-o-anisamide, 4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl]-2-methoxybenzamide, aminosultopride, Solian
Amisulpride, sold under the brand names Socian and Barhemsys, is a medication used in the treatment of schizophrenia, acute psychotic episodes, depression, and nausea and vomiting. It is specifically used at lower doses intravenously to prevent and treat postoperative nausea and vomiting, at low doses by mouth to treat depression, and at higher doses by mouth to treat psychosis.
Key facts
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~16 min read
Article
26 sectionsContents
- Medical uses
- Schizophrenia
- Depression
- Postoperative nausea and vomiting
- Available forms
- Contraindications
- Adverse effects
- Discontinuation
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- United States clinical development
- {{anchor|Society and culture}}Society and culture
- Brand names
- Availability
- Research
- Bipolar depression
- Chemotherapy-induced nausea and vomiting
- Chemical derivatives
- See also
- References
- External links
Amisulpride, sold under the brand names Socian and Barhemsys, is a medication used in the treatment of schizophrenia, acute psychotic episodes, depression, and nausea and vomiting. It is specifically used at lower doses intravenously to prevent and treat postoperative nausea and vomiting, at low doses by mouth to treat depression, and at higher doses by mouth to treat psychosis.
It is usually classed with the atypical antipsychotics. Chemically it is a benzamide and like other benzamide antipsychotics, such as sulpiride, it is associated with a high risk of elevating blood levels of the lactation hormone, prolactin (thereby potentially causing the absence of the menstrual cycle, breast enlargement, even in males, breast milk secretion not related to breastfeeding, impaired fertility, impotence, breast pain, etc.), and a low risk, relative to the typical antipsychotics, of causing movement disorders.