Structure via PubChem · Public domain (PubChem)
(RS)-dobutamine
Sign in to saveAlso known as DL-dobutamine, 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine, rac-dobutamine, racemic-dobutamine, 4-{2-[3-(4-hydroxy-phenyl)-1-methyl-propylamino]-ethyl}-benzene-1,2-diol, (+-)-4-(2-{[3-(p-hydroxyphenyl)-1-methylpropyl]amino}ethyl)pyrocatechol, dobutamine
Dobutamine is a medication used in the treatment of cardiogenic shock (as a result of inadequate tissue perfusion) and severe heart failure. It may also be used in certain types of cardiac stress tests. It is given by IV only, as an injection into a vein or intraosseous as a continuous infusion. The amount of medication needs to be adjusted to the desired effect. Onset of effects is generally seen within 2 minutes. It has a half-life of two minutes. This drug is generally only administered short term, although it may be used for longer periods to relieve symptoms of heart failure in patients a
Chemical data
- Formula
- C18H23NO3
- Molecular weight
- 301.4 g/mol
- IUPAC name
- 4-[2-[4-(4-hydroxyphenyl)butan-2-ylamino]ethyl]benzene-1,2-diol
- SMILES
- CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O
- InChIKey
- JRWZLRBJNMZMFE-UHFFFAOYSA-N
- XLogP
- 3.4
- Polar surface area
- 72.7 Ų
- H-bond donors
- 4
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
52 papers- Natural Sympathomimetic Drugs: From Pharmacology to Toxicology.Biomolecules · 2022
- IMPROVE-DiCE, a 2-Part, Open-Label, Phase 2a Trial Evaluating the Safety and Effectiveness of Ninerafaxstat in Patients With Cardiometabolic Syndromes.Circulation · 2026
- Dobutamine stress echocardiography, myocardial perfusion scintigraphy, invasive coronary angiography, and post-liver transplantation events: Systematic review and meta-analysis.Clinical transplantation · 2018
- Time to re-think the use of dobutamine in sepsis.Journal of intensive care · 2017
- Blood pressure control with phenylephrine or dobutamine: a randomized controlled trial comparing effects on cerebral and paravertebral tissue oxygen saturation measured with near-infrared spectroscopy.Journal of clinical monitoring and computing · 2023
via PubMed
Wikidata facts
- Mass
- 301.168
- Manufacturer
- Pfizer
Show 8 more facts
- chemical formula
- C₁₈H₂₃NO₃
- Commons category
- Dobutamine
- World Health Organisation international non-proprietary name
- dobutamine
- canonical SMILES
- CC(CCC1=CC=C(C=C1)O)NCCC2=CC(=C(C=C2)O)O
- defined daily dose
- 0.5
- medical condition treated
- heart disease
- physically interacts with
- adrenoceptor beta 2
- stylized name
- DOBUTamine
Sources (9)
via Wikidata · CC0
~5 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Adverse effects
- Pharmacology
- History
- References
- External links
{{Drugbox | verifiedrevid = 459442789 | IUPAC_name = (RS)-4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol | image = Dobutamine.svg | image_class = skin-invert-image | width = 250 | chirality = Racemic mixture
| tradename = Dobutrex, Inotrex, others | Drugs.com = | MedlinePlus = a682861 | DailyMedID = Dobutamine | pregnancy_AU = B2 | pregnancy_AU_comment = | pregnancy_US = B | pregnancy_US_comment = | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Intravenous, intraosseous | class = β1-agonist
Excerpted from Wikipedia’s “(RS)-dobutamine” article, available under the CC BY-SA 4.0 licence.