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Structure via PubChem · Public domain (PubChem)
S-18986
Sign in to saveAlso known as S 18986
S-18986 is a positive allosteric modulator of the AMPA receptor related to cyclothiazide. It has nootropic and neuroprotective effects in animal studies, and induces both production of BDNF and AMPA-mediated release of noradrenaline and acetylcholine in the hippocampus and frontal cortex of the brain.
Chemical data
- Formula
- C10H12N2O2S
- Molecular weight
- 224.28 g/mol
- IUPAC name
- (3aS)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide
- SMILES
- C1C[C@@H]2NS(=O)(=O)C3=CC=CC=C3N2C1
- InChIKey
- MNTIJYGEITVWHU-SNVBAGLBSA-N
- XLogP
- 1.4
- Polar surface area
- 57.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 224.061949
Show 3 more facts
- chemical formula
- C₁₀H₁₂N₂O₂S
- isomeric SMILES
- C1C[C@@H]2NS(=O)(=O)C3=CC=CC=C3N2C1
- canonical SMILES
- C1CC2NS(=O)(=O)C3=CC=CC=C3N2C1
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
S-18986 is a positive allosteric modulator of the AMPA receptor related to cyclothiazide. It has nootropic and neuroprotective effects in animal studies, and induces both production of BDNF and AMPA-mediated release of noradrenaline and acetylcholine in the hippocampus and frontal cortex of the brain.
==See also== AMPA receptor positive allosteric modulator
Excerpted from Wikipedia’s “S-18986” article, available under the CC BY-SA 4.0 licence.