satraplatin
Sign in to saveAlso known as JM-216, Bis-acetatoamminedichlorocyclohexylamine platinum(IV), BMY 45594, BMY-45594, JM216
Satraplatin (INN, codenamed JM216) is a platinum-based antineoplastic agent that was under investigation as a treatment of patients with advanced prostate cancer who have failed previous chemotherapy. It has not yet received approval from the U.S. Food and Drug Administration. First mentioned in the medical literature in 1993, satraplatin is the first orally active platinum-based chemotherapeutic drug; other available platinum analogues—cisplatin, carboplatin, and oxaliplatin—must be given intravenously.
Research
198 papers- Satraplatin for the therapy of castration-resistant prostate cancer.Future oncology (London, England) · 2009
- The resurgence of platinum-based cancer chemotherapy.Nature reviews. Cancer · 2007
- Satraplatin: leading the new generation of oral platinum agents.Expert opinion on investigational drugs · 2009
- Clinical and pharmacokinetic evaluation of satraplatin.Expert opinion on drug metabolism & toxicology · 2012
- Satraplatin Demonstrates High Cytotoxic Activity Against Genetically Defined Lymphoid Malignancies.Anticancer research · 2022
via PubMed
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Encyclopedic overview
6 sectionsContents
- Mode of action
- Clinical development
- Side effects
- Possible risks and complications
- Detailed mechanism of action
- References
Satraplatin (INN, codenamed JM216) is a platinum-based antineoplastic agent that was under investigation as a treatment of patients with advanced prostate cancer who have failed previous chemotherapy. It has not yet received approval from the U.S. Food and Drug Administration. First mentioned in the medical literature in 1993, satraplatin is the first orally active platinum-based chemotherapeutic drug; other available platinum analogues—cisplatin, carboplatin, and oxaliplatin—must be given intravenously.
The drug has also been used in the treatment of lung and ovarian cancers. The proposed mode of action is that the compound binds to the DNA of cancer cells rendering them incapable of dividing.
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