SEC23IP
Sign in to saveAlso known as P125, P125A, MSTP053, SEC23 interacting protein, iPLA1beta
SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to SEC23IP, and connects out to PubMed, human chromosome 10 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 10.
Vinony links it to 5 Wikipedia language editions.
Gene data
SEC23IP- Name
- SEC23 interacting protein
- Type
- protein-coding
- Position
- 119,892,593–119,944,657 (+)
- Aliases
- MSTP053, P125, P125A, iPLA1A, iPLA1beta
- Ensembl
- ENSG00000107651
- RefSeq RNA
- NM_001411070.1, NM_007190.4, NR_037771.2, XM_047424537.1, XM_054364654.1
- RefSeq protein
- NP_001397999.1, NP_009121.1, XP_047280493.1, XP_054220629.1
This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SEC23 interacting protein
- Symbol
- SEC23IP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:119,892,593-119,944,657
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 38288
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/11196
- genomic end
- 119944657
- genomic start
- 119892730
- chromosome
- human chromosome 10
- cytogenetic location
- 10q26.11-q26.12
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.
COPII-coated vesicles are involved in protein transport from the Endoplasmic Reticulum to the Golgi Apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.
Excerpted from Wikipedia’s “SEC23IP” article, available under the CC BY-SA 4.0 licence.