SIVA1

Also known as CD27BP, SIVA, Siva-1, Siva-2, SIVA1 apoptosis inducing factor

Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene. This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.

Gene data

SIVA1

Name: SIVA1 apoptosis inducing factor
Type: protein-coding
Position: 104,753,122–104,768,494 (+)
Aliases: CD27BP, SIVA, Siva-1, Siva-2
Ensembl: ENSG00000184990
RefSeq RNA: NM_006427.4, NM_021709.3, XM_011536360.3, XM_054375275.1
RefSeq protein: NP_006418.2, NP_068355.1, XP_011534662.1, XP_054231250.1

This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018].