Also known as LT, TNFB, TNFSF1, Lymphotoxin alpha, TNLG1E
protein-coding gene in the species Homo sapiens
Gene data
LTA- Name
- lymphotoxin alpha
- Type
- protein-coding
- Chromosome
- HSCHR6_MHC_QBL_CTG1
- Position
- 2,827,871–2,830,143 (+)
- Aliases
- LT, TNFB, TNFSF1, TNLG1E
- Ensembl
- ENSG00000173503
- RefSeq RNA
- NM_000595.4, NM_001159740.2, XM_047418773.1, XM_054329823.1, XM_054329824.1
- RefSeq protein
- NP_000586.2, NP_001153212.1, XP_047274729.1, XP_054185798.1, XP_054185799.1
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
lymphotoxin alpha
- Symbol
- LTA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_MANN_CTG1:2,877,095-2,879,365
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein LTA PDB 1tnr.png
Show 9 more facts
- found in taxon
- Homo sapiens
- HomoloGene ID
- 497
- exact match
- identifiers.org/ncbigene/4049
- chromosome
- human chromosome 6
- genomic start
- 31539831
- genomic end
- 31542101
- cytogenetic location
- 6p21.33
- Commons category
- Lymphotoxin alpha
- expressed in
- bone marrow
via Wikidata · CC0