Also known as TNFC, TNFSF3, p33, Lymphotoxin beta, TNLG1C
protein-coding gene in the species Homo sapiens
In the Vinony graph
Vinony's link graph records 161 inbound references to LTB, and connects out to PubMed, tumor necrosis factor and Ensembl genome database project.
It sits within the topics Cytokines and Genes on human chromosome 6.
Vinony links it to 6 Wikipedia language editions.
Gene data
LTB- Name
- lymphotoxin beta
- Type
- protein-coding
- Position
- 31,580,525–31,582,522 (−)
- Aliases
- TNFC, TNFSF3, TNLG1C, p33
- Ensembl
- ENSG00000236925
- RefSeq RNA
- NM_002341.2, NM_009588.1
- RefSeq protein
- NP_002332.1, NP_033666.1
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
lymphotoxin beta
- Symbol
- LTB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- Chr HSCHR6_MHC_MANN_CTG1:2,885,596-2,887,563
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 1752
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4050
- chromosome
- human chromosome 6
- genomic start
- 31548302
- genomic end
- 31550299
- cytogenetic location
- 6p21.33
Sources (4)
via Wikidata · CC0