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GeneQ18047446· pop 5· linked from 4 articles

SLA2

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Also known as C20orf156, MARS, SLAP-2, SLAP2, Src-like-adaptor 2, Src like adaptor 2

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.

In the Vinony graph

Within Vinony's link graph, SLA2 is referenced by 4 other articles, and connects out to PubMed, human chromosome 20 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 20.

Its subject is documented across 5 Wikipedia language editions.

Gene data

SLA2

Name: Src like adaptor 2
Type: protein-coding
Position: 36,612,318–36,646,219 (−)
Aliases: C20orf156, MARS, SLAP-2, SLAP2
Ensembl: ENSG00000101082
RefSeq RNA: NM_032214.4, NM_175077.3
RefSeq protein: NP_115590.1, NP_778252.1

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II B cell mediated immunity T cell activation T cell activation regulation of immune response negative regulation of calcium-mediated signaling antigen receptor-mediated signaling pathway negative regulation of T cell receptor signaling pathway

Molecular function

protein binding signaling adaptor activity signaling adaptor activity

Cellular component

cytoplasm cytoplasm late endosome cytosol cytosol plasma membrane plasma membrane endosome membrane

Pathways

Cytokine Signaling in Immune system Immune System FLT3 Signaling Negative regulation of FLT3

via MyGene.info

Gene · Ensembl

Src like adaptor 2

Symbol: SLA2
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:36,612,318-36,646,219
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 49989
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/84174
genomic end: 36646196
genomic start: 35240721
chromosome: human chromosome 20
cytogenetic location: 20q11.23

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.

== Function ==

Excerpted from Wikipedia’s “SLA2” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 20