SPEN
Sign in to saveAlso known as HIAA0929, MINT, RBM15C, SHARP, spen family transcriptional repressor, RATARS
gen de la especie Homo sapiens
In the Vinony graph
Within Vinony's link graph, SPEN is referenced by 7 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Its subject is documented across 9 Wikipedia language editions.
Gene data
SPEN- Name
- spen family transcriptional repressor
- Type
- protein-coding
- Position
- 15,836,095–15,940,456 (+)
- Aliases
- HIAA0929, MINT, RATARS, RBM15C, SHARP
- Ensembl
- ENSG00000065526
- RefSeq RNA
- NM_015001.3
- RefSeq protein
- NP_055816.2
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
spen family transcriptional repressor
- Symbol
- SPEN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:15,836,095-15,940,456
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SPEN PDB 1ow1.png
Show 8 more facts
- HomoloGene ID
- 124461
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23013
- genomic end
- 15940456
- genomic start
- 15836095
- chromosome
- human chromosome 1
- cytogenetic location
- 1p36.21-p36.13
- expressed in
- ascending aorta
Sources (4)
via Wikidata · CC0
Article · Español
La proteína de interacción Msx2 (SPEN) es una proteína codificada en humanos por el gen SPEN. Este gen codifica un represor transcripcional inducible por hormonas. La represión de la transcripción ejercida por esta proteína puede producirse por medio de interacciones con otros represores, por el reclutamiento de proteínas implicadas en la deacetilación de histonas o a través del secuestro de activadores transcripcionales. La proteína SPEN contiene un dominio C-terminal que le permite unirse a otros correpresores. Este dominio también permite la interacción con miembros del complejo implicado en la remodelación del nucleosoma, que posee actividad deacetilasa. Además, este represor contiene varios motivos de reconocimiento de ARN que confieren la capacidad de unirse al coactivador ARN del receptor esteroideo. De este modo, esta unión puede modular la actividad de receptores esteroideos tanto libres como unidos a ligando.
Abstract from DBpedia / Wikipedia · CC BY-SA