SPOP
Sign in to saveAlso known as BTBD32, TEF2, speckle type BTB/POZ protein, NEDMIDF, NSDVS1, NSDVS2, NEDMACE
Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.
In the Vinony graph
Within Vinony's link graph, SPOP is referenced by 4 other articles, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 17.
Its subject is documented across 6 Wikipedia language editions.
Gene data
SPOP- Name
- speckle type BTB/POZ protein
- Type
- protein-coding
- Position
- 49,598,884–49,678,201 (−)
- Aliases
- BTBD32, NEDMACE, NEDMIDF, NSDVS1, NSDVS2, TEF2
- Ensembl
- ENSG00000121067
- RefSeq RNA
- NM_001007226.1, NM_001007227.1, NM_001007228.2, NM_001007229.1, NM_001007230.1
- RefSeq protein
- NP_001007227.1, NP_001007228.1, NP_001007229.1, NP_001007230.1, NP_001007231.1
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
speckle type BTB/POZ protein
- Symbol
- SPOP
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:49,598,884-49,678,201
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SPOP PDB 2cr2.png
Show 8 more facts
- HomoloGene ID
- 68354
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8405
- genomic end
- 49678163
- genomic start
- 47676246
- chromosome
- human chromosome 17
- cytogenetic location
- 17q21.33
- expressed in
- smooth muscle tissue
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- DNA repair
- Clinical relevance
- References
- Further reading
Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.
Excerpted from Wikipedia’s “SPOP” article, available under the CC BY-SA 4.0 licence.