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GeneQ424737· pop 5

Also known as ASV, SRC1, c-SRC, p60-Src, SRC proto-oncogene, non-receptor tyrosine kinase, THC6

enzym

Gene data

SRC
Name
SRC proto-oncogene, non-receptor tyrosine kinase
Type
protein-coding
Position
37,344,673–37,406,050 (+)
Aliases
ASV, SRC1, THC6, c-SRC, p60-Src
RefSeq RNA
NM_005417.5, NM_198291.3, XM_017028026.2, XM_047440396.1, XM_047440397.1
RefSeq protein
NP_005408.1, NP_938033.1, XP_016883515.1, XP_047296352.1, XP_047296353.1

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

SRC proto-oncogene, non-receptor tyrosine kinase

Symbol
SRC
Biotype
Protein coding
Organism
Homo sapiens
Location
20:37,344,673-37,406,050
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
21120
found in taxon
Homo sapiens
genomic start
35973088
genomic end
36034453
cytogenetic location
20q11.23
Sources (3)

via Wikidata · CC0

Article · Svenska

Proto-oncogene tyrosine-protein kinase Src eller Src är ett enzym som kodas av genen SRC.Src uttalas "Sark", eftersom det är en kortform av sarkom, en form av cancer. Enzymet aktiveras av ett annat enzym kallat FAK när celler binder till extracellulärt matrix, vilket initierar en signaltransduktionsväg som orsakar bland annat ökad celldelning och minskad apoptos. Föga förvånande är mutationer på Src eller Src-reglerande enzymer ofta onkogena, det vill säga ger upphov till cancerceller.

Abstract from DBpedia / Wikipedia · CC BY-SA

Available in 5 languages

via Wikidata sitelinks · CC0