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GeneQ18031207· pop 6· linked from 833 articles

RORC

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Also known as NR1F3, RORG, RZR-GAMMA, RZRG, TOR, RAR-related orphan receptor gamma, IMD42, RAR related orphan receptor C

protein-coding gene in the species Homo sapiens

Gene data

RORC

Name: RAR related orphan receptor C
Type: protein-coding
Position: 151,806,071–151,831,845 (−)
Aliases: IMD42, NR1F3, RORG, RZR-GAMMA, RZRG, TOR
Ensembl: ENSG00000143365
RefSeq RNA: NM_001001523.2, NM_005060.4, XM_006711484.5, XM_047427201.1, XM_054338086.1
RefSeq protein: NP_001001523.1, NP_005051.2, XP_006711547.3, XP_047283157.1, XP_054194061.1

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II tolerance induction in gut-associated lymphoid tissue regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II xenobiotic metabolic process circadian rhythm regulation of gene expression

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm nuclear body

Pathways

Th17 cell differentiation - Homo sapiens (human)Circadian rhythm - Homo sapiens (human)Inflammatory bowel disease - Homo sapiens (human)Cytokine Signaling in Immune system Immune System Generic Transcription Pathway Generic Transcription Pathway Nuclear Receptor transcription pathway Signaling by Interleukins Interleukin-4 and Interleukin-13 signaling

via MyGene.info

Gene · Ensembl

RAR related orphan receptor C

Symbol: RORC
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:151,806,021-151,831,845
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: RORC 3L0L.png

Show 5 more facts

HomoloGene ID: 21051
exact match: identifiers.org/ncbigene/6097
genomic end: 151831845
genomic start: 151778547
cytogenetic location: 1q21.3

Sources (8)

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Categories

Genes on human chromosome 1 Intracellular receptors Transcription factors