SRGAP2
Sign in to saveAlso known as ARHGAP34, FNBP2, SRGAP2A, SRGAP3, SLIT-ROBO Rho GTPase activating protein 2
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2), also known as formin-binding protein 2 (FNBP2), is a mammalian protein that in humans is encoded by the SRGAP2 gene. It is involved in neuronal migration and differentiation and plays a critical role in synaptic development, brain mass and number of cortical neurons. Downregulation of srGAP2 inhibits cell–cell repulsion and enhances cell–cell contact duration.
Gene data
SRGAP2- Name
- SLIT-ROBO Rho GTPase activating protein 2
- Type
- protein-coding
- Aliases
- ARHGAP34, FNBP2, SRGAP2A
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014].
via MyGene.info
Gene · Ensembl
SLIT-ROBO Rho GTPase activating protein 2
- Symbol
- SRGAP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:206,203,346-206,464,436
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 52683
- exact match
- identifiers.org/ncbigene/23380
- genomic start
- 206203346
- genomic end
- 206464436
- cytogenetic location
- 1q32.1
Sources (3)
via Wikidata · CC0
~2 min read
Article
3 sectionsContents
- {{Anchor|Gene duplication}}Evolution
- References
- External links
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2), also known as formin-binding protein 2 (FNBP2), is a mammalian protein that in humans is encoded by the SRGAP2 gene. It is involved in neuronal migration and differentiation and plays a critical role in synaptic development, brain mass and number of cortical neurons. Downregulation of srGAP2 inhibits cell–cell repulsion and enhances cell–cell contact duration.
SRGAP2 dimerizes through its F-BAR domain. SRGAP2C, a shortened version found in early hominins and humans that only has the F-BAR domain, antagonizes its action. It slows maturation of some neurons and increases neuronal spine density. SRGAP2 may also be involved in the development of some cancers.