SRGAP2
Sign in to saveAlso known as ARHGAP34, FNBP2, SRGAP2A, SRGAP3, SLIT-ROBO Rho GTPase activating protein 2
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2), also known as formin-binding protein 2 (FNBP2), is a mammalian protein that in humans is encoded by the SRGAP2 gene. It is involved in neuronal migration and differentiation and plays a critical role in synaptic development, brain mass and number of cortical neurons. Downregulation of srGAP2 inhibits cell–cell repulsion and enhances cell–cell contact duration.
In the Vinony graph
Vinony's link graph records 8 inbound references to SRGAP2, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under topics including Developmental genes and proteins and Genes on human chromosome 1.
Vinony links it to 10 Wikipedia language editions.
Gene data
SRGAP2- Name
- SLIT-ROBO Rho GTPase activating protein 2
- Type
- protein-coding
- Position
- 206,203,346–206,464,436 (+)
- Aliases
- ARHGAP34, FNBP2, SRGAP2A
- Ensembl
- ENSG00000266028
- RefSeq RNA
- NM_001042758.1, NM_001170637.4, NM_001300952.2, NM_001377444.1, NM_001377445.1
- RefSeq protein
- NP_001164108.1, NP_001287881.1, NP_001364373.1, NP_001364374.1, NP_001364375.1
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SLIT-ROBO Rho GTPase activating protein 2
- Symbol
- SRGAP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:206,203,346-206,464,436
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 52683
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/23380
- chromosome
- human chromosome 1
- genomic start
- 206203346
- genomic end
- 206464436
- cytogenetic location
- 1q32.1
- expressed in
- monocyte
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- {{Anchor|Gene duplication}}Evolution
- References
- External links
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2), also known as formin-binding protein 2 (FNBP2), is a mammalian protein that in humans is encoded by the SRGAP2 gene. It is involved in neuronal migration and differentiation and plays a critical role in synaptic development, brain mass and number of cortical neurons. Downregulation of srGAP2 inhibits cell–cell repulsion and enhances cell–cell contact duration.
SRGAP2 dimerizes through its F-BAR domain. SRGAP2C, a shortened version found in early hominins and humans that only has the F-BAR domain, antagonizes its action. It slows maturation of some neurons and increases neuronal spine density. SRGAP2 may also be involved in the development of some cancers.
Excerpted from Wikipedia’s “SRGAP2” article, available under the CC BY-SA 4.0 licence.