STX2
Sign in to saveAlso known as EPIM, EPM, STX2A, STX2B, STX2C, syntaxin 2
Syntaxin-2, also known as epimorphin, is a protein that in humans is encoded by the STX2 gene.
Gene data
STX2- Name
- syntaxin 2
- Type
- protein-coding
- Position
- 130,789,600–130,839,265 (−)
- Aliases
- EPIM, EPM, STX2A, STX2B, STX2C
- Ensembl
- ENSG00000111450
- RefSeq RNA
- NM_001351049.2, NM_001351050.2, NM_001351051.2, NM_001351052.2, NM_001413773.1
- RefSeq protein
- NP_001337978.2, NP_001337979.1, NP_001337980.1, NP_001337981.1, NP_001400702.1
The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
syntaxin 2
- Symbol
- STX2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:130,789,597-130,839,297
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- exact match
- identifiers.org/ncbigene/2054
- HomoloGene ID
- 37559
- genomic end
- 131323811
- genomic start
- 131274145
- cytogenetic location
- 12q24.33
via Wikidata · CC0
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Article
3 sectionsContents
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- Further reading
Syntaxin-2, also known as epimorphin, is a protein that in humans is encoded by the STX2 gene.
The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. When the N terminus is on the cytosolic face it acts as a t-SNARE involved in intracellular vesicle docking and is called Syntaxin-2. When flipped inside out, i.e. N terminus hangs out on the extracellular surface (by some nonclassical secretion pathway) it acts as a versatile morphogen and is called epimorphin. This membrane protein enjoys the double choice of another form of topological alternatives of being targeted to either apical or basolateral surface of an epithelial cell in a regulated way depending on various contexts. When expressed by mesenchymal cells it can instruct epithelial morphogenesis at epithelial mesenchymal interfaces.